Trends Genet. 1990 Jul;6(7):219-23.

Human globin locus activation region (LAR): role in temporal control.

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Department of Biochemistry, School of Medicine, University of Alabama, Birmingham 35294.

Abstract

A region of DNA located far upstream of the human beta-globin locus is critically involved in the regulation of the beta-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.

PMID:: 2202110; [PubMed - indexed for MEDLINE]

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Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. [Nature. 1990]
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.
Enver T, Raich N, Ebens AJ, Papayannopoulou T, Costantini F, Stamatoyannopoulos G. Nature. 1990 Mar 22; 344(6264):309-13.
Human gamma- to beta-globin gene switching in transgenic mice. [Genes Dev. 1990]
Human gamma- to beta-globin gene switching in transgenic mice.
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Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions. [Proc Natl Acad Sci U S A. 1990]
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Moon AM, Ley TJ. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7693-7.
Review The regulation of human globin gene switching. [Philos Trans R Soc Lond B Biol...]
Review The regulation of human globin gene switching.
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Cited by 35 PubMed Central articles

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