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Trends Genet. 1990 Jul;6(7):213-8.

Inherited predisposition to cancer.

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  • 1CRC Human Cancer Genetics Research Group, Department of Pathology, University of Cambridge, UK.


In a minority of cancers, the family history, and sometimes characteristic abnormalities in growth or development of target tissues, suggests strong inherited predisposition. There may also be a much larger number of cases who are less strongly predisposed, with important implications for screening and prevention; because there is usually no family history, however, the recognition and investigation of these cases poses a major problem.

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