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Mol Cell Endocrinol. 2012 Mar 31;351(1):28-36. doi: 10.1016/j.mce.2011.10.006. Epub 2011 Oct 15.

The cAMP pathway and the control of adrenocortical development and growth.

Author information

  • 1CNRS UMR6247, INSERM U931, Génétique Reproduction et Développement, Clermont Université, Aubière, France.

Abstract

In the last 10 years, extensive studies showed that the cAMP pathway is deregulated in patients suffering from adrenocortical tumours, and particularly in primary pigmented nodular adrenocortical disease (PPNAD). Here we describe how evidence arising from the analysis of patients' data, mouse models and in vitro experiments, have shed light on the cAMP pathway as a central player in adrenal physiopathology. We also show how novel data generated from mouse models may point to new targets for potential therapies.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
22019902
[PubMed - indexed for MEDLINE]
PMCID:
PMC3678347
Free PMC Article

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