Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroimage. 2012 Feb 1;59(3):2142-54. doi: 10.1016/j.neuroimage.2011.10.018. Epub 2011 Oct 14.

Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.

Author information

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. powerj@wusm.wustl.edu

Erratum in

  • Neuroimage. 2012 Nov 1;63(2):999.

Abstract

Here, we demonstrate that subject motion produces substantial changes in the timecourses of resting state functional connectivity MRI (rs-fcMRI) data despite compensatory spatial registration and regression of motion estimates from the data. These changes cause systematic but spurious correlation structures throughout the brain. Specifically, many long-distance correlations are decreased by subject motion, whereas many short-distance correlations are increased. These changes in rs-fcMRI correlations do not arise from, nor are they adequately countered by, some common functional connectivity processing steps. Two indices of data quality are proposed, and a simple method to reduce motion-related effects in rs-fcMRI analyses is demonstrated that should be flexibly implementable across a variety of software platforms. We demonstrate how application of this technique impacts our own data, modifying previous conclusions about brain development. These results suggest the need for greater care in dealing with subject motion, and the need to critically revisit previous rs-fcMRI work that may not have adequately controlled for effects of transient subject movements.

Copyright © 2011 Elsevier Inc. All rights reserved.

Comment in

PMID:
22019881
[PubMed - indexed for MEDLINE]
PMCID:
PMC3254728
Free PMC Article

Images from this publication.See all images (10)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk