Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2011 Dec;34(12):611-8. doi: 10.1016/j.tins.2011.09.003. Epub 2011 Oct 22.

New insights into the relationship between dopamine, beta oscillations and motor function.

Author information

  • 1Nuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

Abstract

Synchronised neuronal oscillations at beta frequencies are prevalent in the human motor system, but their function is unclear. In this Opinion article, we propose that the levels of beta oscillations provide a measure of the likelihood that a new voluntary action will need to be actuated. Oscillatory beta activity is in turn modulated by net dopamine levels at sites of cortical input to the basal ganglia. We hypothesise that net dopamine levels are modulated in response to salient internal and external cues. Crucially, the resulting modulation of beta activity is predictive, enabling the appropriate prospective resourcing and preparation of potential actions. Loss of dopamine, as in Parkinson's disease, annuls this function, unless net dopaminergic activity can be elevated through medication.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22018805
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk