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    Cancer Lett. 2012 Jan 28;314(2):206-12. Epub 2011 Oct 1.

    70-Gene classifier for differentiation between paclitaxel- and docetaxel-sensitive breast cancers.

    Naoi Y, Tanei T, Kishi K, Tsunashima R, Tominaga N, Baba Y, Nakayama T, Shimazu K, Kim SJ, Tamaki Y, Noguchi S.

    Source

    Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

    Abstract

    Association of estrogen receptor (ER), progesterone receptor (PR), HER2, Ki67 and 70-gene classifier (70-GC) with a response to paclitaxel (PAC) (n=79) or docetaxel (DOC) (n=55) was investigated in the neoadjuvant setting for breast cancer patients. Sensitivity of breast tumors to PAC, but not to DOC, was found to be significantly associated with ER negativity (P=0.003), PR negativity (P=0.007), and Ki67 positivity (P=0.007). Breast tumors classified into the responders by 70-GC showed a significantly (P=0.005) higher reduction rate to PAC and interestingly a significantly (P=0.009) lower reduction rate to DOC than those classified into the non-responders by 70-GC, suggesting that 70-GC might be useful for the differentiation of PAC-sensitive and DOC-sensitive breast tumors.

    Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

    PMID:
    22018777
    [PubMed - indexed for MEDLINE]

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