Mol Cell. 2011 Oct 21;44(2):170-1.

Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.

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Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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In this issue of Molecular Cell, Hirschey et al. demonstrate that loss of the NAD(+)-dependent deacetylase SIRT3 and resultant mitochondrial protein hyperacetylation play a critical role in the pathogenesis of metabolic syndrome, providing new insights into the therapeutic potential of SIRT3.

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Mol Cell. 2011 Oct 21;44(2):177-90.

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PMCID:: PMC3215590; [Available on 2012/10/21]

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. [Mol Cell. 2011]
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, et al. Mol Cell. 2011 Oct 21; 44(2):177-90.
Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase. [Biochem J. 2008]
Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase.
Hallows WC, Albaugh BN, Denu JM. Biochem J. 2008 Apr 15; 411(2):e11-3.
NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. [J Biol Chem. 2010]
NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.
Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, et al. J Biol Chem. 2010 Mar 5; 285(10):7417-29. Epub 2009 Dec 30.
Review Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart. [Am J Physiol Heart Circ Physio...]
Review Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart.
Sack MN. Am J Physiol Heart Circ Physiol. 2011 Dec; 301(6):H2191-7. Epub 2011 Oct 7.
Review Mitochondrial sirtuins. [Biochim Biophys Acta. 2010]
Review Mitochondrial sirtuins.
Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Biochim Biophys Acta. 2010 Aug; 1804(8):1645-51. Epub 2010 Jan 7.

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Mitochondrial SIRT3: a new potential therapeutic target for metabolic syndrome.

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