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Nat Rev Mol Cell Biol. 2011 Oct 21;12(11):749-56. doi: 10.1038/nrm3212.

Imaging the coordination of multiple signalling activities in living cells.

Author information

  • 1Department of Pharmacology and Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Abstract

Cellular signal transduction occurs in complex and redundant interaction networks, which are best understood by simultaneously monitoring the activation dynamics of multiple components. Recent advances in biosensor technology have made it possible to visualize and quantify the activation of multiple network nodes in the same living cell. The precision and scope of this approach has been greatly extended by novel computational approaches (referred to as computational multiplexing) that can reveal relationships between network nodes imaged in separate cells.

PMID:
22016058
[PubMed - indexed for MEDLINE]
PMCID:
PMC3773929
Free PMC Article

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