Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bioorg Med Chem Lett. 2011 Dec 1;21(23):7068-71. doi: 10.1016/j.bmcl.2011.09.096. Epub 2011 Sep 29.

A small molecule that preferentially binds the closed conformation of Hsp90.

Author information

  • 1Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.

Abstract

Described is the synthesis of three different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90). Using fluorescence polarization anisotropy, we report the binding affinity of these fluorescein-labeled compounds to Hsp90 in its open state and ATP-dependent closed state. We show that the compounds demonstrate a conformation-dependent preference for binding to the closed state.

Published by Elsevier Ltd.

PMID:
22014826
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Chemical Information

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk