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Cancer Cell. 2011 Oct 18;20(4):420-3. doi: 10.1016/j.ccr.2011.10.004.

The spliceosome as an indicted conspirator in myeloid malignancies.

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  • 1Human Oncology and Pathogenesis Program, Leukemia Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.


Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing.

Copyright © 2011 Elsevier Inc. All rights reserved.

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  • Frequent pathway mutations of splicing machinery in myelodysplasia. [Nature. 2011]
  • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. [N Engl J Med. 2011]
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