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Cancer Cell. 2011 Oct 18;20(4):418-20. doi: 10.1016/j.ccr.2011.10.005.

Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

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  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
22014567
[PubMed]
PMCID:
PMC3226726
Free PMC Article
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