Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Pharmacol Ther. 2011 Nov;90(5):646-8. doi: 10.1038/clpt.2011.199.

Registration of observational studies does not enhance validity.

Author information

  • 1Department of Epidemiology, Brown University, Providence, Rhode Island, USA. david_savitz@brown.edu

Abstract

Mandatory registration of observational studies has been proposed to enhance quality of published research and reduce selective publication of positive findings. Enhanced communication of study plans would be welcome, but the alleged benefits to research quality are illusory. In particular, prespecification of hypotheses has no independent effect on data quality or the likelihood that hypotheses are correct. Registration of studies and hypotheses is likely to be misinterpreted as an independent determinant of validity.

PMID:
22012311
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk