Clin Pharmacol Ther. 2011 Nov;90(5):645-6. doi: 10.1038/clpt.2011.171.

Integration of diverse data sources for prediction of adverse drug events.

Abernethy DR, Bai JP, Burkhart K, Xie HG, Zhichkin P.

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Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. darrell.abernethy@fda.hhs.gov

Abstract

The rapid evolution of large biological, pharmacological, and chemical databases has led to optimism that such data resources can be leveraged for prediction of drug action based on molecular descriptors of the drug. Challenges to realize this possibility include organization of each type of database in a manner that allows extraction of information across disparate data sources and the linkage of information across the biological, pharmacological, and chemical domains.

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Clin Pharmacol Ther. 2011 Nov;90(5):662-5.

PMID:: 22012310; [PubMed - indexed for MEDLINE]

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