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Genome Biol. 2011 Oct 18;12(10):R101. doi: 10.1186/gb-2011-12-10-r101.

SpeCond: a method to detect condition-specific gene expression.

Author information

  • 1EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK. florence@ebi.ac.uk

Erratum in

  • Genome Biol. 2011;12(12):413. Huber, Wolfgang [removed].

Abstract

Transcriptomic studies routinely measure expression levels across numerous conditions. These datasets allow identification of genes that are specifically expressed in a small number of conditions. However, there are currently no statistically robust methods for identifying such genes. Here we present SpeCond, a method to detect condition-specific genes that outperforms alternative approaches. We apply the method to a dataset of 32 human tissues to determine 2,673 specifically expressed genes. An implementation of SpeCond is freely available as a Bioconductor package at http://www.bioconductor.org/packages/release/bioc/html/SpeCond.html.

PMID:
22008066
[PubMed - indexed for MEDLINE]
PMCID:
PMC3333772
Free PMC Article

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