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J Nucleic Acids. 2012;2012:687359. doi: 10.1155/2012/687359. Epub 2011 Oct 9.

p53 Family: Role of Protein Isoforms in Human Cancer.

Author information

  • 1Department of Surgery and Cancer Biology, Vanderbilt University Medical Center, 1255 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA.

Abstract

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.

PMID:
22007292
[PubMed]
PMCID:
PMC3191818
Free PMC Article

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