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Pediatr Infect Dis J. 2011 Dec;30(12):1100-3. doi: 10.1097/INF.0b013e318232ee3e.

Evolution of the epidemiology of pneumococcal disease among Utah children through the vaccine era.

Author information

  • 1Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA. krow.ampofo@hsc.utah.edu

Abstract

From 1996 to 2009, we analyzed changes in pneumococcal disease (PD) in Utah children aged <18 years using International Classification of Diseases, ninth revision coded hospital discharges. We observed a sustained decrease in the incidence of PD among children <5 years in 2001-2004 (-36%) and 2005-2009 (-34%) compared with 1996-2000 (pre-7-valent pneumococcal conjugate vaccine). Decreases were primarily in bacteremia, uncomplicated pneumonia, and meningitis. In contrast, significant increases in complicated pneumonia/empyema were noted in children <5 years (+95% and +85%) and 5 to 17 years (+2% and +70%). Despite decreases in PD among Utah children, complicated pneumonia/empyema has increased during the 7-valent pneumococcal conjugate vaccine era.

PMID:
22005513
[PubMed - indexed for MEDLINE]
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