Biochem Biophys Res Commun. 2011 Oct 28;414(3):631-4. Epub 2011 Oct 6.

Sexually dimorphic gene expression in non-human primate ESCs analyzed stringently.

Shweiki D, Ben-Yehudah A, Redinger C, Easley CA 4th, Doron S, Schatten G.

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Bioinformatics Program, School of Computer Science, The Academic College of Tel Aviv-Yaffo, Tel Aviv, Israel. dorits@mta.ac.il

Abstract

Human exhibit sexual dimorphism early in development and throughout life. Here we stringently analyzed gene expression in inbred non-human primate embryonic stem cells (nhpESCs) searching for sexually dimorphisms. We utilized location-specific probes solely, thus avoiding probe cross-reactivity between members of gene families and genomic gene duplications. Seventeen sexually dimorphic transcripts (15 genes, out of which 9 autosomals) were identified, of which five were verified using real-time q-PCR. We compared these results from pedigreed nhpESCs with available human ESCs datasets. Three human X-linked genes show sexual dimorphism. Thus, these results enhance our knowledge and deepen our understanding on early development processes for sexual dimorphism.

PMID:: 22005468; [PubMed - indexed for MEDLINE]

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Sexually dimorphic gene expression in non-human primate ESCs analyzed stringently.

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