Send to:

Choose Destination
See comment in PubMed Commons below
Environ Toxicol Pharmacol. 2011 Nov;32(3):472-7. doi: 10.1016/j.etap.2011.09.002. Epub 2011 Sep 10.

Changes of thyroid hormone levels and related gene expression in zebrafish on early life stage exposure to triadimefon.

Author information

  • 1Institute of Pesticide and Environmental Toxicology, Zhejiang University, Kaixuan Road 268, Hangzhou, Zhejiang 310029, PR China.


In this study, zebrafish was exposed to triadimefon. Thyroid hormones levels and the expression of related genes in the hypothalamic-pituitary-thyroid (HPT) axis, including thyroid-stimulating hormone (TSH-beta), deiodinases (dio1 and dio2) and the thyroid hormone receptor (thraa and thrb) were evaluated. After triadimefon exposure, increased T4 can be explained by increased thyroid-stimulating hormone (TSH-beta). The conversion of T4 to T3 (deiodinase type I-dio1) was decreased, which reduced the T3 level. Thyroid hormone receptor beta (thrb) mRNA levels were significantly down-regulated, possibly as a response to the decreased T3 levels. The overall results indicated that triadimefon exposure could alter gene expression in the HPT axis and that mechanisms of disruption of thyroid status by triadimefon could occur at several steps in the synthesis, regulation, and action of thyroid hormones.

Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk