Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Neurol. 2011 Oct;70(4):657-61. doi: 10.1002/ana.22509. Epub 2011 Oct 14.

Amyloid-β associated volume loss occurs only in the presence of phospho-tau.

Author information

  • 1Department of Radiology, University of California-San Diego, La Jolla 92037, CA.

Abstract

The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF Aβ(1-42) . We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ(1-42) only with elevated CSF p-tau(181p) . Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia.

Copyright © 2011 American Neurological Association.

PMID:
22002658
[PubMed - indexed for MEDLINE]
PMCID:
PMC3368003
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk