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Hormones (Athens). 2011 Jul-Sep;10(3):236-40.

Growth hormone deficiency: an unusual presentation of floating harbor syndrome.

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  • 1Fourth Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital Thessaloniki, Greece. galtsin@otenet.gr


Floating-Harbor Syndrome (FHS) is a very rare condition of unknown etiology characterized by short stature, delayed bone age, characteristic facial features, delayed language skills and usually normal motor development. This syndrome has only once been associated with growth hormone deficiency and precocious puberty in the same patient. We describe a 5 4/12 year-old girl with the typical features of FHS in whom growth hormone deficiency was diagnosed and two years later central precocious puberty was noted. The patient showed a good response to human recombinant growth hormone as well as gonadotropin releasing hormone analogue treatment.

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