Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Nephrol. 2011 Sep;31(5):459-65. doi: 10.1016/j.semnephrol.2011.08.011.

Uric acid as a mediator of diabetic nephropathy.

Author information

  • 1Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA. Diana.Jalal@ucdenver.edu

Abstract

Despite advances in the management of patients with diabetes, diabetic nephropathy (DN) remains the most common cause of end-stage renal disease in the United States and worldwide. Inflammation and endothelial dysfunction appear to play a central role in the onset and the progression of DN. Recent evidence has emerged in the past decade to suggest uric acid is an inflammatory factor and may play a role in endothelial dysfunction. This has lead our group and others to explore the role of uric acid in the onset and progression of DN. In this review, we highlight some of the animal and human studies that implicate uric acid in DN. Based on the evidence we review, we conclude the need for properly planned randomized controlled studies to decrease uric acid levels and assess the impact of such therapy on diabetic kidney disease.

Published by Elsevier Inc.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk