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J Neurol Sci. 2011 Dec 15;311(1-2):32-6. doi: 10.1016/j.jns.2011.08.041. Epub 2011 Oct 13.

Vitamin D-gene interactions in multiple sclerosis.

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  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK.

Abstract

Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
22000399
[PubMed - indexed for MEDLINE]
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