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    J Neuroimmunol. 2011 Oct 28;239(1-2):44-52. Epub 2011 Oct 13.

    Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release.

    Vichaya EG, Young EE, Frazier MA, Cook JL, Welsh CJ, Meagher MW.

    Source

    Dept. of Psychology, College of Liberal Arts, Texas A&M University, United States.

    Abstract

    Chronic social disruption stress (SDR) exacerbates acute and chronic phase Theiler's murine encephalomyelitis virus (TMEV) infection, a mouse model of multiple sclerosis. However, the precise mechanism by which this occurs remains unknown. The present study suggests that SDR exacerbates TMEV disease course by priming virus-induced neuroinflammation. It was demonstrated that IL-1β mRNA expression increases following acute SDR; however, IL-6 mRNA expression, but not IL-1β, is upregulated in response to chronic SDR. Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1β mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation.

    Copyright © 2011 Elsevier B.V. All rights reserved.

    PMID:
    22000153
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3205213
    [Available on 2012/10/28]

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