Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochem Cell Biol. 2012 Feb;90(1):1-13. doi: 10.1139/o11-042. Epub 2011 Oct 14.

ATP-dependent chromatin remodeling in T cells.

Author information

  • 1National Institute on Aging, Intramural Research Program, Laboratory of Molecular Biology and Immunology, Biomedical Research Center, Baltimore, MD 21224, USA.

Abstract

One of the best studied systems for mammalian chromatin remodeling is transcriptional regulation during T cell development. The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly, these findings have also advanced our knowledge of the function of remodeling enzymes in mammalian gene regulation. First we briefly present biochemical and cell-free analysis of 3 types of ATP dependent remodeling enzymes (SWI/SNF, Mi2, and ISWI) to construct an intellectual framework to understand how these enzymes might be working. Second, we compare and contrast the function of these enzymes during early (thymic) and late (peripheral) T cell development. Finally, we examine some of the gaps in our present understanding.

PMID:
21999456
[PubMed - indexed for MEDLINE]
PMCID:
PMC3424609
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk