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Biochem Cell Biol. 2012 Feb;90(1):1-13. doi: 10.1139/o11-042. Epub 2011 Oct 14.

ATP-dependent chromatin remodeling in T cells.

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  • 1National Institute on Aging, Intramural Research Program, Laboratory of Molecular Biology and Immunology, Biomedical Research Center, Baltimore, MD 21224, USA.


One of the best studied systems for mammalian chromatin remodeling is transcriptional regulation during T cell development. The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly, these findings have also advanced our knowledge of the function of remodeling enzymes in mammalian gene regulation. First we briefly present biochemical and cell-free analysis of 3 types of ATP dependent remodeling enzymes (SWI/SNF, Mi2, and ISWI) to construct an intellectual framework to understand how these enzymes might be working. Second, we compare and contrast the function of these enzymes during early (thymic) and late (peripheral) T cell development. Finally, we examine some of the gaps in our present understanding.

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