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J Sep Sci. 2011 Nov;34(21):3107-13. doi: 10.1002/jssc.201100455. Epub 2011 Oct 14.

Supercritical extraction of phloroglucinol and benzophenone derivatives from Hypericum carinatum: quantification and mathematical modeling.

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  • 1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.


The aerial parts of Hypericum carinatum (Guttiferae) were extracted with supercritical carbon dioxide under constant temperature (40, 50 or 60°C) and gradual pressure increase (90, 120, 150 and 200 bar) aiming at the recovery of enriched fractions containing uliginosin B, cariphenone A and cariphenone B, compounds of pharmaceutical interest. The yields of these substances were determined by high-performance liquid chromatography and compared with those obtained with n-hexane maceration. The supercritical-fluid extraction showed higher selectivity than the conventional solvent extraction method. After defining 40°C and 90 bar as the best conditions to obtain the target compounds, a mathematical model was used for the extraction process and a good correlation was achieved with the experimental data.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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