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Curr Biol. 2011 Oct 11;21(19):R807-9. doi: 10.1016/j.cub.2011.09.006.

Nuclear architecture: the cell biology of a laminopathy.

Author information

  • Department of Molecular Biosciences, Northwestern University, Hogan 2100, Evanston, IL 60201, USA. j-brickner@northwestern.edu

Abstract

Lamin mutations cause muscular dystrophies, but the mechanism is unclear. A new study shows that lamin mutant worms display muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to altered gene expression.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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PMID:
21996501
[PubMed - indexed for MEDLINE]
PMCID:
PMC3970426
Free PMC Article

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