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Viruses. 2011 Jul;3(7):982-1000. doi: 10.3390/v3070982. Epub 2011 Jun 27.

Correlates of immunity to filovirus infection.

Author information

  • 1United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland, MD 21702, USA. steven.bradfute@us.army.mil

Abstract

Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment.

KEYWORDS:

ebola; filovirus; immunity; marburg

PMID:
21994766
[PubMed - indexed for MEDLINE]
PMCID:
PMC3185794
Free PMC Article
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