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Curr Opin Pharmacol. 2011 Dec;11(6):612-6. doi: 10.1016/j.coph.2011.09.006. Epub 2011 Oct 10.

MicroRNA involvement in esophageal carcinogenesis.

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  • 1Department of Internal Medicine, Greater Baltimore Medical Center, Baltimore, MD, United States. sdavid@gbmc.org


MicroRNAs (miRs) have recently emerged as a novel class of gene expression regulators. The number of studies documenting an altered miR expression pattern in cancer continues to expand rapidly. Critical information is continuously gained regarding how aberrantly expressed miRs contribute to carcinogenesis. Current studies provide evidence that analyses of miR expression patterns have potential clinical applications toward developing tumor biomarkers to identify the presence and dissemination of esophageal cancer, as well as to assess tumor chemosensitivity or radiosensitivity. The incidence of esophageal cancer is on the rise, and this disease continues to portend a poor prognosis. The current review addresses ways in which altered miR expression contributes to esophageal carcinogenesis, along with how recent discoveries may be applied clinically.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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