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J Infect Dis. 2011 Nov;204 Suppl 3:S892-6. doi: 10.1093/infdis/jir311.

Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication.

Author information

  • 1Filovirus Laboratory, INSERM U758, Human Virology Department, Universit√© de Lyon, Ecole Normale Sup√©rieure de Lyon, Lyon, France.

Abstract

The structural protein VP24 of Ebola virus (EBOV) is a determinant of virulence in rodent models and possesses an interferon antagonist function. In this study, we investigate the role of VP24 in EBOV replication using RNA interference by small interfering RNA to knock down the expression of this protein in virus-infected cells. We reveal that VP24 is required for assembly of viral nucleocapsids and that silencing of VP24 expression prevents the release of EBOV.

PMID:
21987766
[PubMed - indexed for MEDLINE]
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