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    J Alzheimers Dis. 2012;28(2):297-301. doi: 10.3233/JAD-2011-111118.

    Simvastatin modulates the Alzheimer's disease-related gene seladin-1.

    Source

    Neuron BIO, BioPharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain.

    Abstract

    This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.

    PMID:
    21987590
    [PubMed - indexed for MEDLINE]

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