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Antimicrob Agents Chemother. 2012 Jan;56(1):428-31. doi: 10.1128/AAC.05456-11. Epub 2011 Oct 10.

Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition.

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  • 1Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia.

Abstract

The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth arrest (dormancy) profile of parasites may be one aspect of this phenotype. In this study, we investigated the link between dormancy and resistance, using artelinic acid (AL)-resistant parasites. Our results demonstrate that the AL resistance phenotype has (i) decreased sensitivity of mature-stage parasites, (ii) decreased sensitivity of the ring stage to the induction of dormancy, and (iii) a faster recovery from dormancy.

PMID:
21986828
[PubMed - indexed for MEDLINE]
PMCID:
PMC3256014
Free PMC Article

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