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Nat Rev Immunol. 2011 Oct 10;11(11):738-49. doi: 10.1038/nri3071.

Macrophage-mediated inflammation in metabolic disease.

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  • 1Cardiovascular Research Institute, University of California San Francisco, California 94158-9001, USA. Ajay.Chawla@ucsf.edu

Abstract

Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease.

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