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Neurobiol Aging. 2011 Dec;32 Suppl 1:S64-6. doi: 10.1016/j.neurobiolaging.2011.09.008. Epub 2011 Oct 8.

Clinical trial methodologies for disease-modifying therapeutic approaches.

Author information

  • Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA. paisen@ucsd.edu

Abstract

In recent years, advances in Alzheimer's disease (AD) biomarker research have provided powerful tools to improve trial design. In particular, biomarkers provide powerful methods for the selection of individuals with Alzheimer's disease prior to the onset of dementia. Data suggest that neuroimaging biomarkers will be useful as endpoints for trials in very early, even asymptomatic disease, though further work is necessary to establish validity for regulatory purposes.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21983242
[PubMed - indexed for MEDLINE]
PMCID:
PMC3232303
Free PMC Article
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