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Cell Metab. 2011 Oct 5;14(4):439-40. doi: 10.1016/j.cmet.2011.09.006.

Of fat, β cells, and diabetes.

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  • 1Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland.


The molecular mechanisms linking diet, obesity, and type 2 diabetes are still poorly understood. In a recent paper, Ohtsubo et al. (2011) show that high lipid levels induce nuclear exclusion of Foxa2 and HNF1α in β cells, leading to impaired expression and glycosylation of proteins controlling glucose-stimulated insulin secretion.

Copyright © 2011 Elsevier Inc. All rights reserved.

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