Source
Université Catholique de Louvain, Cliniques Universitaires St. Luc, Department of Gynecology, Brussels, Belgium. jacques.donnez@uclouvain.be
Abstract
OBJECTIVE:
To report the restoration of ovarian function in a woman with Turner syndrome by allografting ovarian cortex from her monozygotic twin.
DESIGN:
Case report.
SETTING:
Gynecology research unit in a university hospital.
PATIENT(S):
A 37-year-old woman with Turner syndrome who had suffered premature ovarian failure (POF) at the age of 15.
INTERVENTION(S):
In this woman, we performed ovarian cortex transplantation. The donor was her monozygotic twin who had not experienced POF and who had had two normal deliveries.
MAIN OUTCOME MEASURE(S):
Restoration of ovarian activity and pregnancy.
RESULT(S):
Restoration of ovarian function was achieved 3 months after transplantation. After 7 months of regular cycles, spontaneous pregnancy occurred. The patient delivered a healthy baby girl weighing 2,850 g at 38 weeks of gestation.
CONCLUSION(S):
Girls with Turner syndrome suffer accelerated loss of ovarian follicles and only 2%-5% experience spontaneous menses with the potential to achieve pregnancy without medical intervention. This manuscript reports the first live birth after allografting between monozygotic twins with 45,XO/46,XX mosaicism and discordant growth pattern and ovarian function.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.