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Department of Pediatrics, Division of Endocrinology, St Johns Hospital and United Hospitals of North-Buda, Buda Children's Hospital, 1023 Bolyai-u. 5-9 Budapest, Hungary. peter_f@budaigyk.hu
This article summarizes the ontogenesis and genetics of the thyroid with regards to its possible congenital dysfunction and briefly refers to the roles of the mother-placenta-fetal unit, iodine effect, and organic and functional changes of the negative feedback mechanism, as well as maturity and illness, in some forms of congenital hypo- and hyperthyroidism. This article also describes the published literature and the authors' data on the clinical aspects of congenital hypothyroidism, on the alternating hypo- and hyperthyroidism in the neonatal period, and on neonatal hyperthyroidism.
Copyright © 2011 Elsevier Inc. All rights reserved.
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