Abstract
Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loading of therapeutics into both the core and shell domains. We characterize MSNP drug-eluting properties in vitro and demonstrate that the polymer-coated MSNPs release doxorubicin in response to proteases present at a tumor site in vivo, resulting in cellular apoptosis. These results demonstrate the utility of polymer-coated nanoparticles in specifically delivering an antitumor payload.
© 2011 American Chemical Society
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antibiotics, Antineoplastic / administration & dosage*
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Antibiotics, Antineoplastic / pharmacology
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Cell Survival / drug effects
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Delayed-Action Preparations / chemistry*
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Delayed-Action Preparations / metabolism
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Doxorubicin / administration & dosage*
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Doxorubicin / pharmacology
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HeLa Cells
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Humans
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Nanoparticles / chemistry*
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Nanoparticles / ultrastructure
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Neoplasms / drug therapy
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Peptide Hydrolases / metabolism
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Polymers / chemistry
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Polymers / metabolism
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Porosity
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Silicon Dioxide / chemistry*
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Silicon Dioxide / metabolism
Substances
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Antibiotics, Antineoplastic
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Delayed-Action Preparations
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Polymers
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Silicon Dioxide
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Doxorubicin
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Peptide Hydrolases