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    J Neuroimmunol. 2011 Oct 28;239(1-2):61-7. Epub 2011 Oct 5.

    The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

    Source

    Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.

    Abstract

    Dysfunction of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) is a primary characteristic of multiple sclerosis (MS). We evaluated the protective effects of fasudil, a selective ROCK inhibitor, in a model of experimental autoimmune encephalomyelitis (EAE) that was induced by guinea-pig spinal cord. In addition, we studied the effects of fasudil on BBB and BSCB permeability. We found that fasudil partly alleviated EAE-dependent damage by decreasing BBB and BSCB permeability. These results provide rationale for the development of selective inhibitors of Rho kinase as a novel therapy for MS.

    Copyright © 2011 Elsevier B.V. All rights reserved.

    PMID:
    21978848
    [PubMed - indexed for MEDLINE]

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