Send to:

Choose Destination
See comment in PubMed Commons below
Diabetes Metab J. 2011 Aug;35(4):384-9. doi: 10.4093/dmj.2011.35.4.384. Epub 2011 Aug 31.

Long menstrual cycle is associated with type 2 diabetes mellitus in korean women.

Author information

  • 1Division of Endocrinology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.



Long menstrual cycle is a risk factor for developing type 2 diabetes and cardiovascular disease in women. We aimed to evaluate the association between existing type 2 diabetes and oligomenorrhea before diagnosis of diabetes, and to observe the differences in this association among obese and non-obese Korean women.


Patients with type 2 diabetes (n=118) and without any clinical evidence of abnormal glucose regulation (n=258) who attended the outpatient clinic of a university hospital and were over age 30. Patients self-reporting a menstrual cycle over 40 days during their 20s were defined as oligomenorrhea before diagnosis of diabetes. Obesity was defined as having a body mass index (BMI) over 25 kg/m(2).


The frequency of oligomenorrhea before diagnosis of diabetes was almost two-fold higher in women with type 2 diabetes than in the control group (16.1% vs. 8.5%, P=0.03). Oligomenorrhea was associated with type 2 diabetes after adjusting for age, BMI, systolic blood pressure, triglycerides, and high density lipoprotein cholesterol (odds ratio, 3.89; 95% confidence interval, 1.37 to 11.04). Among women with oligomenorrhea before diagnosis of diabetes, the frequency of type 2 diabetes was significantly higher in obese subjects than in their non-obese counterparts (90.9% vs. 30.0%, P=0.03).


Having a long menstrual cycle could be a risk factor for the development of type 2 diabetes, especially in obese women.


Diabetes mellitus; Obesity; Oligomenorrhea

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Korean Diabetes Association Icon for PubMed Central
    Loading ...
    Write to the Help Desk