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Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):79-102. doi: 10.1002/wsbm.162. Epub 2011 Oct 4.

Regulatory gene network circuits underlying T cell development from multipotent progenitors.

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  • 1Division of Biology, California Institute of Technology, Pasadena, CA, USA.

Abstract

Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function.

Copyright © 2011 John Wiley & Sons, Inc.

PMID:
21976153
[PubMed - indexed for MEDLINE]
PMCID:
PMC3242926
Free PMC Article

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