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Appl Radiat Isot. 2012 Jan;70(1):205-9. doi: 10.1016/j.apradiso.2011.09.005. Epub 2011 Sep 17.

Automated synthesis of [18F]gefitinib on a modular system.

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  • 1Philips Research Europe, Department of Biomolecular Engineering, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands.


In recent years, [(18)F]gefitinib PET has successfully been employed for a number of applications ranging from oncology to in vivo studies of drug transporter proteins. We here report a reliable, automated procedure for routine synthesis of this radiotracer on an Eckert and Ziegler modular system. The 3-step radiosynthesis followed by preparative HPLC-purification provided [(18)F]gefitinib in 17.2±3.3% (n=22) overall decay-corrected radiochemical yield with radiochemical purity >99% in a total synthesis time of about 2.5h.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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