Abstract
New evidence has revealed interesting aspects of how the Wnt-β-catenin pathway controls self-renewal and lineage differentiation of pluripotent embryonic stem cells. Although Wnt-β-catenin signaling is dispensable for the self-renewal of naive mouse embryonic stem cells, it facilitates their expansion and resistance to differentiation through an unconventional dual mechanism involving the transcriptional repressor T cell factor (TCF) 3 and the transcriptional activator TCF1.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / physiology*
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Hepatocyte Nuclear Factor 1-alpha / genetics
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Hepatocyte Nuclear Factor 1-alpha / metabolism
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Mice
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Pluripotent Stem Cells / cytology
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Pluripotent Stem Cells / physiology*
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Wnt Proteins / genetics
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Wnt Proteins / metabolism*
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Wnt Signaling Pathway / physiology*
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beta Catenin / genetics
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Hepatocyte Nuclear Factor 1-alpha
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Hnf1a protein, mouse
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Tcf3 protein, mouse
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Wnt Proteins
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beta Catenin