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    J Neurochem. 2011 Dec;119(6):1282-93. doi: 10.1111/j.1471-4159.2011.07514.x. Epub 2011 Nov 9.

    Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model.

    Jeong YH, Kim JM, Yoo J, Lee SH, Kim HS, Suh YH.

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    Department of Pharmacology, College of Medicine, National Creative Research Initiative Centre for Alzheimer's Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, Korea.

    Abstract

    Various environmental factors are known to influence the onset and progression of Alzheimer's disease (AD). Environmental enrichment was reported to improve cognitive performance in various Alzheimer's transgenic mice via an amyloid-related or unrelated mechanism. However, stress has been found to accelerate amyloid deposition and cognitive deficits in many AD models. The aim of this study was to determine whether environmental enrichment compensates for the effects of stress on disease progression in the Tg2576 mice, an established AD model. We housed Tg2576 mice under environmental enrichment, enrichment plus stress, stress, or control conditions at 3 months of age. In this study, we first report that environmental enrichment counteracts the effects of stress in terms of cognitive deficits, tau phosphorylation, neurogenesis, and neuronal proliferation during AD-like disease progression. These results strongly implicate the importance of environmental factors as a major modulator for the disease progression of AD.

    © 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry.

    PMID:
    21967036
    [PubMed - indexed for MEDLINE]

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