Pharmacotherapy. 1990;10(3):157-74.

The pharmacology of adenosine.

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Likoff Cardiovascular Institute, Hahnemann University, Philadelphia, PA 19102-1192.

Abstract

Adenosine is a purine nucleoside present in every cell of the human body. It is released into the extracellular space under physiologic and pathophysiologic conditions characterized by increased oxygen demand:supply ratio. Adenosine can exert a wide spectrum of effects in various organs and tissues. Exogenous adenosine has a wide spectrum of effects in experimental animal models as well as humans. The pharmacokinetics, pharmacodynamics, and the interaction of adenosine with other drugs are reviewed.

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