Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
Cassavaugh JM, Hale SA, Wellman TL, Howe AK, Wong C, Lounsbury KM.
J Cell Biochem. 2011 Dec;112(12):3882-90. doi: 10.1002/jcb.23321.
Related citations
MCM proteins are negative regulators of hypoxia-inducible factor 1.
Hubbi ME, Luo W, Baek JH, Semenza GL.
Mol Cell. 2011 Jun 10;42(5):700-12.
HDAC2 promotes cell migration/invasion abilities through HIF-1α stabilization in human oral squamous cell carcinoma.
Chang CC, Lin BR, Chen ST, Hsieh TH, Li YJ, Kuo MY.
J Oral Pathol Med. 2011 Aug;40(7):567-75. doi: 10.1111/j.1600-0714.2011.01009.x. Epub 2011 Feb 18.
Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein.
Choi YK, Kim CK, Lee H, Jeoung D, Ha KS, Kwon YG, Kim KW, Kim YM.
J Biol Chem. 2010 Oct 15;285(42):32116-25. Epub 2010 Aug 19.
Targeted knockdown of SEPT9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway.
Amir S, Golan M, Mabjeesh NJ.
Mol Cancer Res. 2010 May;8(5):643-52. Epub 2010 Apr 20.
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL.
J Biol Chem. 2010 Feb 5;285(6):3651-63. Epub 2009 Nov 23.
c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner.
Yu B, Miao ZH, Jiang Y, Li MH, Yang N, Li T, Ding J.
Cancer Res. 2009 Oct 1;69(19):7704-12. Epub 2009 Sep 8.
Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.
André H, Pereira TS.
J Biol Chem. 2008 Oct 24;283(43):29375-84. Epub 2008 Aug 11.
Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H.
Mol Pharmacol. 2008 Jul;74(1):236-45. Epub 2008 Apr 21.
Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation.
Kim BY, Kim H, Cho EJ, Youn HD.
Exp Mol Med. 2008 Feb 29;40(1):71-83.
Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.
Park SS, Bae I, Lee YJ.
J Cell Biochem. 2008 Apr 15;103(6):1989-98.
Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL.
J Biol Chem. 2007 Dec 21;282(51):37064-73. Epub 2007 Oct 26.
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL.
J Biol Chem. 2007 Nov 16;282(46):33358-66. Epub 2007 Sep 17.
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL.
J Biol Chem. 2007 Aug 10;282(32):23572-80. Epub 2007 Jun 8.
Constitutive/hypoxic degradation of HIF-alpha proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein.
Kong X, Alvarez-Castelao B, Lin Z, Castaño JG, Caro J.
J Biol Chem. 2007 May 25;282(21):15498-505. Epub 2007 Apr 2.
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.
Fu B, Xue J, Li Z, Shi X, Jiang BH, Fang J.
Mol Cancer Ther. 2007 Jan;6(1):220-6.
Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I.
Biol Reprod. 2006 Jul;75(1):112-21. Epub 2006 Apr 12.
MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis.
Amir S, Wang R, Matzkin H, Simons JW, Mabjeesh NJ.
Cancer Res. 2006 Jan 15;66(2):856-66.
VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.
Li Z, Wang D, Messing EM, Wu G.
EMBO Rep. 2005 Apr;6(4):373-8.
NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms.
Zhong H, Willard M, Simons J.
Int J Cancer. 2004 Nov 20;112(4):585-95.
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on