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Virus Res. 2011 Dec;162(1-2):126-37. doi: 10.1016/j.virusres.2011.09.025. Epub 2011 Sep 22.

Structural insights into the rhabdovirus transcription/replication complex.

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  • 1UMI 3265 UJF-EMBL-CNRS Unit of Virus Host Cell Interactions, 6 rue Jules Horowitz, 38042 Grenoble Cedex 9, France.

Abstract

The rhabdoviruses have a non-segmented single stranded negative-sense RNA genome. Their multiplication in a host cell requires three viral proteins in addition to the viral RNA genome. The nucleoprotein (N) tightly encapsidates the viral RNA, and the N-RNA complex serves as the template for both transcription and replication. The viral RNA-dependent RNA polymerase is a two subunit complex that consists of a large subunit, L, and a non-catalytic cofactor, the phosphoprotein, P. P also acts as a chaperone of nascent RNA-free N by forming a N(0)-P complex that prevents N from binding to cellular RNAs and from polymerizing in the absence of RNA. Here, we discuss the recent molecular and structural studies of individual components and multi-molecular complexes that are involved in the transcription/replication complex of these viruses with regard to their implication in viral transcription and replication.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21963663
[PubMed - indexed for MEDLINE]
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