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Ann Allergy Asthma Immunol. 2011 Oct;107(4):364-70. doi: 10.1016/j.anai.2011.07.014.

Nasal carbon dioxide for the symptomatic treatment of perennial allergic rhinitis.

Author information

  • 1Division of Allergy and Immunology, Creighton University, Omaha, Nebraska, USA. tbcasale@creighton.edu

Abstract

BACKGROUND:

Brief nasal carbon dioxide insufflation has previously been shown to provide rapid relief of the symptoms of allergic rhinitis.

OBJECTIVE:

To examine the safety and efficacy of nasal carbon dioxide on the symptoms of perennial allergic rhinitis.

METHODS:

This was a randomized, double-blind, placebo-controlled, multicenter, in-clinic study that evaluated 2 flow rates (5 or 10 mL/s) and 2 administration durations (10 or 30 seconds per nostril) for nasal carbon dioxide vs placebo. Study participants rated their symptoms in clinic for 4 hours after administration and then through 24 hours outside the clinic. A total of 348 symptomatic patients with a minimum 2-year history of perennial allergic rhinitis requiring pharmacotherapy were randomized and treated.

RESULTS:

The mean change in total nasal symptom score from baseline at 30 minutes (the primary end point) showed greater improvement in the nasal carbon dioxide-treated groups compared with placebo. This change was statistically significant in the group treated with 10 mL/s for 10 seconds per nostril: -4.69 carbon dioxide vs -2.00 placebo (P = .03). The effect of a single dose lasted approximately 4 to 6 hours. The mean change from baseline at 30 minutes in total nonnasal symptom score was also statistically significant (-4.06 carbon dioxide vs -2.25 placebo, P = .029) for this group. The most common adverse events were nasal discomfort, lacrimation, and headache.

CONCLUSION:

The study provides further evidence that nasal carbon dioxide is a potentially efficacious treatment for the symptoms of allergic rhinitis.

Copyright © 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

PMID:
21962098
[PubMed - indexed for MEDLINE]
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