Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
J Gastrointestin Liver Dis. 2011 Sep;20(3):315-9.

Autoimmune pancreatitis with response to chemoradiation therapy.

Author information

  • 1Division of Endoscopy, Shizuoka Cancer Center, Shizuoka 411-8777, Japan. h.matsubayashi@scchr.jp

Abstract

Autoimmune pancreatitis (AIP) sometimes mimics pancreatic cancer, and is rarely resected under this misdiagnosis. However, there is no report in the literature regarding a case of AIP, which was misdiagnosed as an inoperative stage of pancreatic cancer and which received systemic chemotherapy with or without radiation. We report a 59-year-old man with a mass-forming lesion at the pancreatic head involving the common hepatic artery and portal vein, initially diagnosed as locally advanced pancreatic cancer and treated with chemoradiation therapy. After a month of continuous infusion of low dose 5-fluorouracil with concurrent local radiation (50.4 Gy), the pancreatic lesion diminished in size. However, the pancreatic body gradually enlarged and a capsule-like limb appeared in the following year. Serological markers and endoscopic retrograde cholangiopancreatography were compatible with those of AIP. No neoplastic tissue was identified on the fine needle aspiration biopsy of the pancreas. The pancreatic lesion responded well to steroid therapy and the patient remained in remission for one year after the withdrawal of steroids. Similar to pancreatic cancer, this current case of AIP responded to chemoradiation. Both serological and histological examinations were essential for images equivocal for either locally advanced pancreatic cancer or AIP.

PMID:
21961103
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Iuliu Hatieganu Medical Publishing House
    Loading ...
    Write to the Help Desk