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J Biomed Biotechnol. 2011;2011:530926. doi: 10.1155/2011/530926. Epub 2011 Sep 22.

A proteome reference map of the causative agent of melioidosis Burkholderia pseudomallei.

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  • 1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. pexcotung@gmail.com

Abstract

Burkholderia pseudomallei is the etiologic agent of melioidosis. Using 2DE and MALDI-TOF MS, we report here a proteome reference map constructed from early stationary phase, a bacterial adaptation process. We identified 282 protein spots representing 220 ORFs; many of them have been implicated in bacterial pathogenesis. Up to 20% of identified ORFs belong to post-translational modification and stress responses. The proteome reference map will support future analysis of the bacterial gene and environmental regulation and facilitate comparative proteomics with its sibling species.

PMID:
21960737
[PubMed - indexed for MEDLINE]
PMCID:
PMC3180641
Free PMC Article
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