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Chembiochem. 2011 Nov 25;12(17):2568-71. doi: 10.1002/cbic.201100540. Epub 2011 Sep 29.

Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.

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  • 1Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0596, USA.

Abstract

Mix'n'match: Enzymatic total synthesis of TDP-D-olivose was achieved, starting from TDP-4-keto-6-deoxy-D-glucose, by combining three pathway enzymes with one cofactor-regenerating enzyme. The results also revealed that MtmC is a bifunctional enzyme that can perform a 4-ketoreduction necessary for D-olivose biosynthesis besides the previously found C-methyltransfer for D-mycarose biosynthesis.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
21960454
[PubMed - indexed for MEDLINE]
PMCID:
PMC3412565
Free PMC Article

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